CONGENITAL MALFORMATIONS – MARKER OF XENOBIOTICS INFLUENCE OF LOW-INTENSITY

Formation of congenital malformations in many respects occurs under the infl uenceof unfavorable stimuli external environment. In its turn, so-called«watch» may be markers ecological troubles.Objective – to analyse frequency malformation origin fetuses and newborns forthe period 2004-2014 conditions their parents living alternative as thepollution districts Chernivtsi region.Material methods. Complex anthropogenic uence on organism was assessedtaking into account bioavailability pollutants soil, water air certainareas region according value environmental risk factor (CER) proposedby us. Data analysis concerning general number with congenitalmalformations for 2004-2018 year carried out. The obtained results theresearch were analyzed means computer package «Statistica 6» Stat Soft andExcell XP Windows a personal using parametric non-parametricmethods calculation.Results. It has been shown that areas ecologicaltrouble(CER≥2.0), development defects constituted48.0%, total such 50.36%. case livingin more favorable (CER<2.0), malformationsdevelopment constituted correspondingly 36.3% 39.0% (p<0.05). Correlationof chances (CCh) newborns, whose parentspermanently lived zones relation group comparison became 1.62 (95% CI: 1-2.6) CI (confi dential interval), native populationCCh 1.59 1-2.8).Conclusion. prolong parents’residence regions high riskof factors low density, gross (watch)malformations, recommended obligatory register EUROCAT, formed thenewborns often than comparison.